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Can You Get Pregnant With Cah?

FAQs Cindy Castillo August 7, 2022

Women with classic CAH can become pregnant during routine maintenance therapy, and it is estimated that 80% and 60% of women with simply virilizing and saline-wasting forms of CAH are fertile, respectively. Most women who stick to maintenance therapy have ovulation rates of up to 40%.

Can people with congenital adrenal hyperplasia get pregnant?

Women with congenital adrenal hyperplasia (CAH) may experience reduced fertility due to increased androgen secretion or impaired sex steroid production. CAH patients have a lower pregnancy rate compared to healthy women. Few cases of successful pregnancy have been reported in the literature.

Can you have children with congenital adrenal hyperplasia?

Congenital adrenal hyperplasia (CAH) during pregnancy is a rare condition. Only a few cases have been described in the literature. CAH patients have a lower pregnancy rate compared to normal women. A 27-year-old nulliparous woman, a diagnosed case of 21-hydroxylase deficiency, simple virilizing form of classic CAH, attended.

How does adrenal hyperplasia cause infertility?

Congenital adrenal hyperplasia (CAH) is the most common genetic steroid disorder affecting fertility. Steroid hormones play a crucial role in sexual development and reproductive function; Patients with either 21-hydroxylase or 11β-hydroxylase deficiency therefore face immense challenges for their fertility.

Can congenital adrenal hyperplasia be passed down?

CAH is a genetic disorder, meaning it is inherited from parents and is present at birth. Children with this condition have two parents who either have CAH themselves or are both carriers of the genetic change that causes the condition. This is known as an autosomal recessive inheritance pattern.

How common is classic CAH?

Classic CAH, the most common form of the disease, affects up to 1 in 10,000 to 15,000 people in the US and Europe. Both classic and non-classic CAH affect people worldwide.

What is the life expectancy of someone with congenital adrenal hyperplasia?

Main outcome measures: mortality and causes of death. Results: The median age at death was 41.2 ± 26.9 years in patients with CAH and 47.7 ± 27.7 years in controls (P<0.001). Of the patients with CAH, 23 (3.9%) had died compared to 942 (1.6%) in the control group.

What is hyperplasia in pregnancy?

When the endometrium, the lining of the womb, becomes too thick, it is called endometrial hyperplasia. This condition is not cancer, but in some cases it can lead to uterine cancer.

How common is late-onset CAH?

It has a prevalence of between 0.1% and 2%, depending on the population, and is one of the most common autosomal recessive genetic disorders in humans. The pathophysiology is complex and not all individuals are symptomatic.

References:

  1. https://journals.lww.com/md-journal/fulltext/2020/12110/successful_pregnancy_and_live_birth_in_woman_with.67.aspx
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742476/
  3. https://pubmed.ncbi.nlm.nih.gov/24355046/
  4. https://www.mayoclinic.org/diseases-conditions/congenital-adrenal-hyperplasia/symptoms-causes/syc-20355205
  5. https://my.clevelandclinic.org/health/diseases/17817-congenital-adrenal-hyperplasia
  6. https://pubmed.ncbi.nlm.nih.gov/25279502/
  7. https://www.acog.org/womens-health/faqs/endometrial-hyperplasia
  8. https://en.wikipedia.org/wiki/Late_onset_congenital_adrenal_hyperplasia

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